Ontology highlight
ABSTRACT:
SUBMITTER: Hauryliuk V
PROVIDER: S-EPMC2483772 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Hauryliuk Vasili V Hansson Sebastian S Ehrenberg Måns M
Biophysical journal 20080523 4
This theoretical work covers structural and biochemical aspects of nucleotide binding and GDP/GTP exchange of GTP hydrolases belonging to the family of small GTPases. Current models of GDP/GTP exchange regulation are often based on two specific assumptions. The first is that the conformation of a GTPase is switched by the exchange of the bound nucleotide from GDP to GTP or vice versa. The second is that GDP/GTP exchange is regulated by a guanine nucleotide exchange factor, which stabilizes a GTP ...[more]