Ontology highlight
ABSTRACT:
SUBMITTER: Lee HX
PROVIDER: S-EPMC2486255 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Lee Hojoon X HX Ambrosio Andrea L AL Reversade Bruno B De Robertis E M EM
Cell 20060101 1
Here we report an unexpected role for the secreted Frizzled-related protein (sFRP) Sizzled/Ogon as an inhibitor of the extracellular proteolytic reaction that controls BMP signaling during Xenopus gastrulation. Microinjection experiments suggest that the Frizzled domain of Sizzled regulates the activity of Xolloid-related (Xlr), a metalloproteinase that degrades Chordin, through the following molecular pathway: Szl -| Xlr -| Chd -| BMP --> P-Smad1 --> Szl. In biochemical assays, the Xlr proteina ...[more]