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Large-scale protein structure modeling of the Saccharomyces cerevisiae genome.

ABSTRACT: The function of a protein generally is determined by its three-dimensional (3D) structure. Thus, it would be useful to know the 3D structure of the thousands of protein sequences that are emerging from the many genome projects. To this end, fold assignment, comparative protein structure modeling, and model evaluation were automated completely. As an illustration, the method was applied to the proteins in the Saccharomyces cerevisiae (baker's yeast) genome. It resulted in all-atom 3D models for substantial segments of 1,071 (17%) of the yeast proteins, only 40 of which have had their 3D structure determined experimentally. Of the 1,071 modeled yeast proteins, 236 were related clearly to a protein of known structure for the first time; 41 of these previously have not been characterized at all.

SUBMITTER: Sanchez R

PROVIDER: S-EPMC24864 | biostudies-literature | 1998 Nov

REPOSITORIES: biostudies-literature

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Large-scale protein structure modeling of the Saccharomyces cerevisiae genome.

Sánchez R R Sali A A

Proceedings of the National Academy of Sciences of the United States of America 19981101 23

The function of a protein generally is determined by its three-dimensional (3D) structure. Thus, it would be useful to know the 3D structure of the thousands of protein sequences that are emerging from the many genome projects. To this end, fold assignment, comparative protein structure modeling, and model evaluation were automated completely. As an illustration, the method was applied to the proteins in the Saccharomyces cerevisiae (baker's yeast) genome. It resulted in all-atom 3D models for s ...[more]

PMID: 9811845

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