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Synthesis of new triazole-based trifluoromethyl scaffolds.

ABSTRACT: Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds.

SUBMITTER: Martinelli M

PROVIDER: S-EPMC2486457 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Synthesis of new triazole-based trifluoromethyl scaffolds.

Martinelli Michela M Milcent Thierry T Ongeri Sandrine S Crousse Benoit B

Beilstein journal of organic chemistry 20080529

Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds. ...[more]

PMID: 18941482

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