Ontology highlight
ABSTRACT:
SUBMITTER: Bonk AJ
PROVIDER: S-EPMC2488202 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Bonk Aaron J AJ Li Rongfeng R Lai Liangxue L Hao Yanhong Y Liu Zhonghua Z Samuel Melissa M Fergason Emily A EA Whitworth Kristin M KM Murphy Clifton N CN Antoniou Eric E Prather Randall S RS
Molecular reproduction and development 20080201 2
Early embryonic development in the pig requires DNA methylation remodeling of the maternal and paternal genomes. Aberrant remodeling, which can be exasperated by in vitro technologies, is detrimental to development and can result in physiological and anatomic abnormalities in the developing fetus and offspring. Here, we developed and validated a microarray based approach to characterize on a global scale the CpG methylation profiles of porcine gametes and blastocyst stage embryos. The relative m ...[more]