Accumulation of GC donor splice signals in mammals.
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ABSTRACT:
SUBMITTER: Churbanov A
PROVIDER: S-EPMC2490688 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Accumulation of GC donor splice signals in mammals.
Churbanov Alexander A Winters-Hilt Stephen S Koonin Eugene V EV Rogozin Igor B IB
Biology direct 20080709
<h4>Unlabelled</h4>The GT dinucleotide in the first two intron positions is the most conserved element of the U2 donor splice signals. However, in a small fraction of donor sites, GT is replaced by GC. A substantial enrichment of GC in donor sites of alternatively spliced genes has been observed previously in human, nematode and Arabidopsis, suggesting that GC signals are important for regulation of alternative splicing. We used parsimony analysis to reconstruct evolution of donor splice sites a ...[more]
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