Ontology highlight
ABSTRACT:
SUBMITTER: Horvilleur E
PROVIDER: S-EPMC2490757 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Horvilleur Emilie E Bauer Matthieu M Goldschneider David D Mergui Xénia X de la Motte Alix A Bénard Jean J Douc-Rasy Sétha S Cappellen David D
Nucleic acids research 20080625 13
MYCN activation, mainly by gene amplification, is one of the most frequent molecular events in neuroblastoma (NB) oncogenesis, and is associated with increased malignancy and decreased neuronal differentiation propensity. The frequency of concomitant loss of heterozygosity at the 1p36.3 locus, which harbours the p53 anti-oncogene homologue TP73, indicates that MYCN and p73 alterations may cooperate in the pathogenesis of NB. We have previously shown that p73 isoforms are deregulated in NB tumour ...[more]