Ontology highlight
ABSTRACT:
SUBMITTER: O'Brien CA
PROVIDER: S-EPMC2491588 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
O'Brien Charles A CA Plotkin Lilian I LI Galli Carlo C Goellner Joseph J JJ Gortazar Arancha R AR Allen Matthew R MR Robling Alexander G AG Bouxsein Mary M Schipani Ernestina E Turner Charles H CH Jilka Robert L RL Weinstein Robert S RS Manolagas Stavros C SC Bellido Teresita T
PloS one 20080813 8
Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone (PTH) stimulates bone remodeling and may cause bone loss or bone gain depending on the balance between bone resorption and formation. Herein, we demonstrate that transgenic mice expressing a constitutively active PTH receptor exclusively in osteocytes ex ...[more]