Ontology highlight
ABSTRACT:
SUBMITTER: Lin YY
PROVIDER: S-EPMC2492751 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Lin Yu-yi YY Qi Yan Y Lu Jin-ying JY Pan Xuewen X Yuan Daniel S DS Zhao Yingming Y Bader Joel S JS Boeke Jef D JD
Genes & development 20080801 15
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that dea ...[more]