Ontology highlight
ABSTRACT:
SUBMITTER: Mina-Osorio P
PROVIDER: S-EPMC2493070 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Mina-Osorio Paola P Winnicka Beata B O'Conor Catherine C Grant Christina L CL Vogel Lotte K LK Rodriguez-Pinto Daniel D Holmes Kathryn V KV Ortega Enrique E Shapiro Linda H LH
Journal of leukocyte biology 20080521 2
During inflammation, cell surface adhesion molecules guide the adhesion and migration of circulating leukocytes across the endothelial cells lining the blood vessels to access the site of injury. The transmembrane molecule CD13 is expressed on monocytes and endothelial cells and has been shown to mediate homotypic cell adhesion, which may imply a role for CD13 in inflammatory monocyte trafficking. Here, we show that ligation and clustering of CD13 by mAb or viral ligands potently induce myeloid ...[more]