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Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.

ABSTRACT: Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83-->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

SUBMITTER: Fu Y 

PROVIDER: S-EPMC2493132 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.

Fu Yingmei Y   Guo Lishuang L   Xu Yan Y   Zhang Wenli W   Gu Jiaao J   Xu Jianfeng J   Chen Xiaobei X   Zhao Yuehui Y   Ma Jiayu J   Liu Xinghan X   Zhang Fengmin F  

Antimicrobial agents and chemotherapy 20080527 8

Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83-->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05). ...[more]

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