Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.
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ABSTRACT:
SUBMITTER: Ban M
PROVIDER: S-EPMC2494944 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.
Ban Maria M Elson Joanna J Walton Amie A Turnbull Douglas D Compston Alastair A Chinnery Patrick P Sawcer Stephen S
PloS one 20080806 8
Several lines of evidence suggest that mitochondrial genetic factors may influence susceptibility to multiple sclerosis. To explore this hypothesis further, we re-sequenced the mitochondrial genome (mtDNA) from 159 patients with multiple sclerosis and completed a haplogroup analysis including a further 835 patients and 1,506 controls. A trend towards over-representation of super-haplogroup U was the only evidence for association with mtDNA that we identified in these samples. In a parallel analy ...[more]
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