Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India.
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ABSTRACT:
SUBMITTER: Pemberton TJ
PROVIDER: S-EPMC2495051 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India.
Pemberton T J TJ Jakobsson M M Conrad D F DF Coop G G Wall J D JD Pritchard J K JK Patel P I PI Rosenberg N A NA
Annals of human genetics 20070530 Pt 4
When performing association studies in populations that have not been the focus of large-scale investigations of haplotype variation, it is often helpful to rely on genomic databases in other populations for study design and analysis - such as in the selection of tag SNPs and in the imputation of missing genotypes. One way of improving the use of these databases is to rely on a mixture of database samples that is similar to the population of interest, rather than using the single most similar da ...[more]
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