Ontology highlight
ABSTRACT:
SUBMITTER: Lee JC
PROVIDER: S-EPMC2495060 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Lee Jenny C JC Weissglas-Volkov Daphna D Kyttälä Mira M Dastani Zari Z Cantor Rita M RM Sobel Eric M EM Plaisier Christopher L CL Engert James C JC van Greevenbroek Marleen M J MM Kane John P JP Malloy Mary J MJ Pullinger Clive R CR Huertas-Vazquez Adriana A Aguilar-Salinas Carlos A CA Tusie-Luna Teresa T de Bruin Tjerk W A TW Aouizerat Bradley E BE van der Kallen Carla C J CC Croce Carlo M CM Aqeilan Rami I RI Marcil Michel M Viikari Jorma S A JS Lehtimäki Terho T Raitakari Olli T OT Kuusisto Johanna J Laakso Markku M Taskinen Marja-Riitta MR Genest Jacques J Pajukanta Päivi P
American journal of human genetics 20080801 2
Low serum HDL-cholesterol (HDL-C) is a major risk factor for coronary artery disease. We performed targeted genotyping of a 12.4 Mb linked region on 16q to test for association with low HDL-C by using a regional-tag SNP strategy. We identified one SNP, rs2548861, in the WW-domain-containing oxidoreductase (WWOX) gene with region-wide significance for low HDL-C in dyslipidemic families of Mexican and European descent and in low-HDL-C cases and controls of European descent (p = 6.9 x 10(-7)). We e ...[more]