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Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.

ABSTRACT: Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology to previously described nuclear hormone receptor corepressors, N-CoR, or SMRT. SUN-CoR is a highly basic, 16-kDa nuclear protein that is expressed at high levels in adult tissues and is induced during adipocyte and myogenic differentiation. SUN-CoR potentiates transcriptional repression by thyroid hormone receptor and RevErb in vivo, represses transcription when fused to a heterologous DNA binding domain, and interacts with RevErb as well as with thyroid hormone receptor in vitro. SUN-CoR also interacts with N-CoR and SMRT in vitro and with endogenous N-CoR in cells. We conclude that SUN-CoR is a corepressor and may function as an additional component of the complex involved in transcriptional repression by unliganded and orphan nuclear hormone receptors.

SUBMITTER: Zamir I 

PROVIDER: S-EPMC24996 | biostudies-literature | 1997 Dec

REPOSITORIES: biostudies-literature

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Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.

Zamir I I   Dawson J J   Lavinsky R M RM   Glass C K CK   Rosenfeld M G MG   Lazar M A MA  

Proceedings of the National Academy of Sciences of the United States of America 19971201 26

Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology to previously described nuclear hormone receptor corepressors, N-CoR, or SMRT. SUN-CoR is a highly basic, 16-kDa nuclear protein that is expressed at high levels in adult tissues and is induced during adipocyte and myogenic differentiation. SUN-CoR potentia  ...[more]

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