TRPP2 and TRPV4 form a polymodal sensory channel complex.
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ABSTRACT:
SUBMITTER: Kottgen M
PROVIDER: S-EPMC2500130 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
TRPP2 and TRPV4 form a polymodal sensory channel complex.
Köttgen Michael M Buchholz Björn B Garcia-Gonzalez Miguel A MA Kotsis Fruzsina F Fu Xiao X Doerken Mara M Boehlke Christopher C Steffl Daniel D Tauber Robert R Wegierski Tomasz T Nitschke Roland R Suzuki Makoto M Kramer-Zucker Albrecht A Germino Gregory G GG Watnick Terry T Prenen Jean J Nilius Bernd B Kuehn E Wolfgang EW Walz Gerd G
The Journal of cell biology 20080801 3
The primary cilium has evolved as a multifunctional cellular compartment that decorates most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular mechanisms that convert the deflection of cilia into intracellular calcium transients have remained elusive. Polycystin-2 (TRPP2), an ion channel mutated in polycystic kidney disease, is required for cilia-mediated calcium transients but lacks mechanosensitive properties. We find here that TRPP2 utilizes TRPV4 to form a ...[more]
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