Ontology highlight
ABSTRACT:
SUBMITTER: Jacob C
PROVIDER: S-EPMC2500137 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Jacob Claire C Grabner Henrik H Atanasoski Suzana S Suter Ueli U
The Journal of cell biology 20080801 3
Transforming growth factor beta (TGFbeta) promotes epithelial cell differentiation but induces Schwann cell proliferation. We show that the protooncogene Ski (Sloan-Kettering viral oncogene homologue) is an important regulator of these effects. TGFbeta down-regulates Ski in epithelial cells but not in Schwann cells. In Schwann cells but not in epithelial cells, retinoblastoma protein (Rb) is up-regulated by TGFbeta. Additionally, both Ski and Rb move to the cytoplasm, where they partially coloca ...[more]