Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki Y
PROVIDER: S-EPMC2504772 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Sasaki Yoshiteru Y Calado Dinis P DP Derudder Emmanuel E Zhang Baochun B Shimizu Yuri Y Mackay Fabienne F Nishikawa Shin-ichi S Rajewsky Klaus K Schmidt-Supprian Marc M
Proceedings of the National Academy of Sciences of the United States of America 20080728 31
BAFF-R-dependent activation of the alternative NF-kappaB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are implicated in human multiple myeloma. We show that overexpression of NIK in mouse B lymphocytes amplifies alternative NF-kappaB activation and peripheral B cell numbers in a BAFF-R-dependent manner, whereas uncoupling NIK from TRAF3-mediated control causes maximal p100 processing and dramatic hyperplasia ...[more]