Ontology highlight
ABSTRACT:
SUBMITTER: Kim KW
PROVIDER: S-EPMC2505330 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Molecular endocrinology (Baltimore, Md.) 20080529 8
The nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the ventromedial hypothalamic nucleus (VMH). Considerable evidence links the VMH and SF-1 with the regulation of energy homeostasis. Here, we demonstrate that SF-1 colocalizes in VMH neurons with the cannabinoid receptor 1 (CB1R) and that a specific CB1R agonist modulates electrical activity of SF-1 neurons in hypothalamic slice preparations. We further show that SF-1 directly regulates CB ...[more]