Ontology highlight
ABSTRACT:
SUBMITTER: Berrettini W
PROVIDER: S-EPMC2507863 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Berrettini W W Yuan X X Tozzi F F Song K K Francks C C Chilcoat H H Waterworth D D Muglia P P Mooser V V
Molecular psychiatry 20080129 4
Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD ...[more]