Ontology highlight
ABSTRACT:
SUBMITTER: Kroeger H
PROVIDER: S-EPMC2515110 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Kroeger Heike H Jelinek Jaroslav J Estécio Marcos R H MR He Rong R Kondo Kimie K Chung Woonbok W Zhang Li L Shen Lanlan L Kantarjian Hagop M HM Bueso-Ramos Carlos E CE Issa Jean-Pierre J JP
Blood 20080603 4
DNA methylation of CpG islands around gene transcription start sites results in gene silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression is not fully understood. We performed genomewide screening for methylated CpG islands and identified 8 genes frequently methylated in leukemia cell lines and in patients with acute myeloid leukemia (AML): NOR1, CDH13, p15, NPM2, OLIG2, PGR, HIN1, and SLC26A4. We assessed the methylation status of these genes and of the rep ...[more]