Ontology highlight
ABSTRACT:
SUBMITTER: Oh S
PROVIDER: S-EPMC2515192 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Oh Sookyung S Park Sunchung S van Nocker Steven S
PLoS genetics 20080822 8
In budding yeast, intragenic histone modification is linked with transcriptional elongation through the conserved regulator Paf1C. To investigate Paf1C-related function in higher eukaryotes, we analyzed the effects of loss of Paf1C on histone H3 density and patterns of H3 methylated at K4, K27, and K36 in Arabidopsis genes, and integrated this with existing gene expression data. Loss of Paf1C did not change global abundance of H3K4me3 or H3K36me2 within chromatin, but instead led to a 3' shift i ...[more]