Ontology highlight
ABSTRACT:
SUBMITTER: Neiss A
PROVIDER: S-EPMC2515204 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Neiss Andrea A Schafmeier Tobias T Brunner Michael M
EMBO reports 20080627 8
FREQUENCY (FRQ) and the White Collar Complex (WCC), consisting of WC1 and WC2 subunits, are crucial components of positive and negative feedback loops of the circadian clock of Neurospora. In the positive limb, FRQ supports the accumulation of WC1 on a post-translational level and activates transcription of wc2. We analysed the transcriptional regulation of wc2. The WCC indirectly inhibits wc2 by controlling expression of a putative repressor. FRQ activates wc2 transcription by inhibiting WCC. A ...[more]