Ontology highlight
ABSTRACT:
SUBMITTER: Hayes KR
PROVIDER: S-EPMC2515491 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Hayes Kevin R KR Zastrow Gina M GM Nukaya Manabu M Pande Kalyan K Glover Ed E Maufort John P JP Liss Adam L AL Liu Yan Y Moran Susan M SM Vollrath Aaron L AL Bradfield Christopher A CA
Chemical research in toxicology 20071020 11
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) serves as a prototype for a range of environmental toxicants and as a pharmacologic probe to study signal transduction by the aryl hydrocarbon receptor (AHR). Despite a detailed understanding of how TCDD exposure leads to the transcriptional up-regulation of cytochrome P450-dependent monooxygenases, we know little about how compounds like TCDD lead to a variety of AHR-dependent toxic end points such as liver pathology, tera ...[more]