Ontology highlight
ABSTRACT:
SUBMITTER: Slatkin M
PROVIDER: S-EPMC2516095 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
A model of unlinked diallelic loci affecting the risk of a complex inherited disease is explored. The loci are equivalent in their effect on disease risk and are in Hardy-Weinberg and linkage equilibrium. The goal is to determine what assumptions about dependence of disease risk on genotype are consistent with data for diseases such as schizophrenia, bipolar disorder, autism, and multiple sclerosis that are relatively common (0.1-2% prevalence) and that have high concordance rates for monozygoti ...[more]