Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC2517117 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Zhang Xingang X Ni Weijuan W van der Donk Wilfred A WA
Organic letters 20070725 17
Lantibiotic synthetases generate intramolecular thioether cross-links within peptides through the Michael-type addition of cysteines onto dehydroamino acids originating from Ser and Thr. Presented here is an assay that readily distinguishes between enzymatic and nonenzymatic formation of these cross-links. The results demonstrate unequivocally that lacticin 481 synthetase can generate non-native thioether cross-links. ...[more]