FSHB promoter polymorphism within evolutionary conserved element is associated with serum FSH level in men.

ABSTRACT:

Background

No polymorphisms affecting serum FSH levels have been described in the human FSHB gene. We have identified a potential regulatory single nucleotide polymorphism (SNP, rs10835638; G/T) 211 bp upstream from the FSHB mRNA transcription start-site, located within a highly conserved region among placental mammals. We aimed to determine the correlation of carrier status of rs10835638 alternative alleles with serum FSH level in men, and testicular and hormonal parameters.

Methods

A quantitative genetic association study using a cohort of healthy men (n = 554; age 19.2 +/- 1.7 years) visiting the Centre of Andrology, Tartu University Hospital, Estonia.

Results

Rs10835638 (allele frequencies: G 87.6%, T 12.4%) was significantly associated with serum FSH level (analy

SUBMITTER: Grigorova M 

PROVIDER: S-EPMC2517155 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature