Ontology highlight
ABSTRACT:
SUBMITTER: Ioanoviciu A
PROVIDER: S-EPMC2518089 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Ioanoviciu Alexandra A Yukl Erik T ET Moënne-Loccoz Pierre P de Montellano Paul R Ortiz PR
Biochemistry 20070320 14
Mycobacterium tuberculosis can exist in the actively growing state of the overt disease or in a latent quiescent state that can be induced, among other things, by anaerobiosis. Eradication of the latent state is particularly difficult with the available drugs and requires prolonged treatment. DevS is a member of the DevS-DevR two-component regulatory system that is thought to mediate the cellular response to anaerobiosis. Here we report the cloning, expression, and initial characterization of a ...[more]