Structural plasticity with preserved topology in the postsynaptic protein network.
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ABSTRACT:
SUBMITTER: Blanpied TA
PROVIDER: S-EPMC2519044 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Structural plasticity with preserved topology in the postsynaptic protein network.
Blanpied Thomas A TA Kerr Justin M JM Ehlers Michael D MD
Proceedings of the National Academy of Sciences of the United States of America 20080822 34
The size, shape, and molecular arrangement of the postsynaptic density (PSD) determine the function of excitatory synapses in the brain. Here, we directly measured the internal dynamics of scaffold proteins within single living PSDs, focusing on the principal scaffold protein PSD-95. We found that individual PSDs undergo rapid, continuous changes in morphology driven by the actin cytoskeleton and regulated by synaptic activity. This structural plasticity is accompanied by rapid fluctuations in i ...[more]
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