Ontology highlight
ABSTRACT:
SUBMITTER: Mansour MM
PROVIDER: S-EPMC2519140 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Mansour Mahmoud M MM Goyal Hari O HO Braden Tim D TD Dennis John C JC Schwartz Dean D DD Judd Robert L RL Bartol Frank F FF Coleman Elaine S ES Morrison Edward E EE
PPAR research 20080101
Exposure to the estrogen receptor alpha (ERalpha) ligand diethylstilbesterol (DES) between neonatal days 2 to 12 induces penile adipogenesis and adult infertility in rats. The objective of this study was to investigate the in vivo interaction between DES-activated ERalpha and the proadipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma). Transcripts for PPARs alpha, beta, and gamma and gamma1a splice variant were detected in Sprague-Dawley normal rat penis w ...[more]