Ontology highlight
ABSTRACT:
SUBMITTER: Kinjo Y
PROVIDER: S-EPMC2519143 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Kinjo Yuki Y Pei Bo B Bufali Simone S Raju Ravinder R Richardson Stewart K SK Imamura Masakazu M Fujio Masakazu M Wu Douglass D Khurana Archana A Kawahara Kazuyoshi K Wong Chi-Huey CH Howell Amy R AR Seeberger Peter H PH Kronenberg Mitchell M
Chemistry & biology 20080701 7
Mouse natural killer T (NKT) cells expressing an invariant T cell antigen receptor (TCR) recognize glycosphingolipids (GSLs) from Sphingomonas bacteria. The synthetic antigens previously tested, however, were designed to closely resemble the potent synthetic agonist alpha-galactosyl ceramide (alphaGalCer), which contains a monosaccharide and a C18:0 sphingosine lipid. Some Sphingomonas bacteria, however, also have oligosaccharide-containing GSLs, and they normally synthesize several GSLs with di ...[more]