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RadC, a misleading name?

ABSTRACT: The pfam04002 annotation describes RadC as a bacterial DNA repair protein. Although the radC gene is expressed specifically during competence for genetic transformation in Streptococcus pneumoniae, we report that radC mutants exhibit normal uptake and processing of transforming DNA. They also display normal sensitivity to DNA-damaging agents, providing no support for the rad epithet.

SUBMITTER: Attaiech L 

PROVIDER: S-EPMC2519389 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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RadC, a misleading name?

Attaiech Laetitia L   Granadel Chantal C   Claverys Jean-Pierre JP   Martin Bernard B  

Journal of bacteriology 20080613 16

The pfam04002 annotation describes RadC as a bacterial DNA repair protein. Although the radC gene is expressed specifically during competence for genetic transformation in Streptococcus pneumoniae, we report that radC mutants exhibit normal uptake and processing of transforming DNA. They also display normal sensitivity to DNA-damaging agents, providing no support for the rad epithet. ...[more]

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