Ontology highlight
ABSTRACT:
SUBMITTER: Kaburagi Y
PROVIDER: S-EPMC2519602 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Organic letters 20070201 4
An operationally simple and efficient workup method for tetrabutylammonium fluoride (TBAF)-mediated t-butyldimethylsilyl (TBS) deprotection has been developed. The procedure includes addition of a sulfonic acid resin and calcium carbonate, followed by filtration and evaporation. This method eliminates the tedious aqueous-phase extraction process to remove excess TBAF and materials derived from TBAF, thereby making the protocol highly amenable to multiple TBS deprotections. Its efficiency and use ...[more]