Ontology highlight
ABSTRACT:
SUBMITTER: Park SW
PROVIDER: S-EPMC2519712 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Park Seung-Won SW Kuroda Mitzi I MI Park Yongkyu Y
Molecular and cellular biology 20080609 16
Despite differences in size and sequence, the two noncoding roX1 and roX2 RNAs are functionally redundant for dosage compensation of the Drosophila melanogaster male X chromosome. Consistent with functional conservation, we found that roX RNAs of distant Drosophila species could complement D. melanogaster roX mutants despite low homology. Deletion of a conserved predicted stem-loop structure in roX2, containing a short GUb (GUUNUACG box) in its 3' stem, resulted in a defect in histone H4K16 acet ...[more]