Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC25201 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Lee S S Wisniewski J C JC Dentler W L WL Asai D J DJ
Molecular biology of the cell 19990301 3
In many organisms, there are multiple isoforms of cytoplasmic dynein heavy chains, and division of labor among the isoforms would provide a mechanism to regulate dynein function. The targeted disruption of somatic genes in Tetrahymena thermophila presents the opportunity to determine the contributions of individual dynein isoforms in a single cell that expresses multiple dynein heavy chain genes. Substantial portions of two Tetrahymena cytoplasmic dynein heavy chain genes were cloned, and their ...[more]