Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2523271 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Organic letters 20061001 22
A straightforward approach toward the total synthesis of frondosin C is described. This strategy involves a key one-pot, microwave-assisted 5-exo cyclization-Claisen rearrangement sequence that was used for the expedient assembly of the frondosic C scaffold. Subsequent manipulation of the tetracyclic core allowed the synthesis of an advanced intermediate bearing the characteristic diene moiety in the B ring. [reaction: see text] ...[more]