Ontology highlight
ABSTRACT:
SUBMITTER: Meadows JC
PROVIDER: S-EPMC2526695 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Meadows John C JC Millar Jonathan J
Molecular biology of the cell 20080618 9
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast. However, we show that Delta mto1 cells, which are defective in nucleation of cytoplasmic microtubules, have profoundly misoriented spindles but are not delayed in the timing of sister chromatid separation, providing compelling evidence that fission yeast does not possess a spindle orientation checkpoint. Instead, we show that l ...[more]