Ontology highlight
ABSTRACT:
SUBMITTER: Moore RE
PROVIDER: S-EPMC2527303 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Moore Rowan E RE Knottenbelt Derek D Matthews Jacqueline B JB Beynon Robert J RJ Whitfield Phillip D PD
BMC veterinary research 20080808
<h4>Background</h4>Ingestion of the poisonous weed ragwort (Senecio jacobea) by horses leads to irreversible liver damage. The principal toxins of ragwort are the pyrrolizidine alkaloids that are rapidly metabolised to highly reactive and cytotoxic pyrroles, which can escape into the circulation and bind to proteins. In this study a non-invasive in vitro model system has been developed to investigate whether pyrrole toxins induce specific modifications of equine blood proteins that are detectabl ...[more]