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A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer.


ABSTRACT: BACKGROUND: The purpose of this study was to evaluate the role of osteoprotegerin gene (OPG) polymorphisms as genetic modifiers in the etiology of prostate cancer (PCa) and disease progression. METHODS: Three hundred and sixty one patients with PCa and 195 normal controls were enrolled in the study, and two genetic polymorphisms, 149 T/C and 950 T/C in the putative promoter region of OPG, were genotyped. RESULTS: There was no significant difference in the genotype frequencies between PCa patients and controls (P = 0.939 and 0.294 for 149 T/C and 950 T/C polymorphisms, respectively). However, those patients with TC and TT genotypes in the 950 T/C polymorphism had a significantly increased risk of extraprostatic (age-adjusted odds ratio; aOR = 1.74 and 2.03 for TC and TT genotypes compared with the CC genotype, P = 0.028) and metastatic disease (aOR = 1.72 and 2.76 for TC and TT genotypes compared with the CC genotype, P = 0.009) compared with those with the CC genotype. In addition, analysis of the metastatic PCa patients (Stage D) showed that the presence of the T allele of the OPG 950 T/C polymorphism was an independent risk factor predicting survival by Cox proportional hazard regression analyses (P = 0.031). CONCLUSION: Progression of PCa may be influenced by an intrinsic genetic factor of the host's bone metabolism. The variant C allele of 950 T/C in the OPG promoter may play a major role as a genetic safe guard against progression in patients with PCa.

SUBMITTER: Narita N 

PROVIDER: S-EPMC2527333 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer.

Narita Naofumi N   Yuasa Takeshi T   Tsuchiya Norihiko N   Kumazawa Teruaki T   Narita Shintaro S   Inoue Takamitsu T   Ma Zhiyong Z   Saito Mitsuru M   Horikawa Yohei Y   Satoh Shigeru S   Ogawa Osamu O   Habuchi Tomonori T  

BMC cancer 20080806


<h4>Background</h4>The purpose of this study was to evaluate the role of osteoprotegerin gene (OPG) polymorphisms as genetic modifiers in the etiology of prostate cancer (PCa) and disease progression.<h4>Methods</h4>Three hundred and sixty one patients with PCa and 195 normal controls were enrolled in the study, and two genetic polymorphisms, 149 T/C and 950 T/C in the putative promoter region of OPG, were genotyped.<h4>Results</h4>There was no significant difference in the genotype frequencies  ...[more]

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