Ontology highlight
ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC2528581 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Ding Yu Y Xi Ying Y Chen Ting T Wang Ji-yong JY Tao Dong-lei DL Wu Zhi-Li ZL Li Yi-ping YP Li Chen C Zeng Rong R Li Lin L
The Journal of cell biology 20080901 5
The low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Frizzled and transmit signals from the plasma membrane to the cytosol. However, the mechanism for LRP5/6 signal transmission remains undefined. Here, we identify cytoplasmic activation/proliferation-associated protein 2 (Caprin-2) as a LRP5/6-binding protein. Our data show that Caprin-2 stabilizes cytosolic beta-catenin and enhances lymphoid enhancer-binding factor 1/T cell factor-dependent reporter gene a ...[more]