Ontology highlight
ABSTRACT:
SUBMITTER: Ko J
PROVIDER: S-EPMC2529058 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Ko Jinkyung J Patel Nihal N Ikawa Tomokatsu T Kawamoto Hiroshi H Frank Oliver O Rivera Richard R RR Van Etten Richard A RA Murre Cornelis C
Proceedings of the National Academy of Sciences of the United States of America 20080825 35
E-proteins are a class of helix-loop-helix (HLH) proteins, which play multiple roles throughout lymphoid development. The DNA binding activities of the E-proteins are regulated by a distinct class of antagonistic HLH proteins, named Id1-4. Here we demonstrate that Id2 deficient mice in a C57BL/6 genetic background exhibit increased cellularity in the granulocyte/myeloid progenitor compartment and show significantly higher numbers of maturing neutrophils. Within 6 months of age, Id2 deficient mic ...[more]