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Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry.

ABSTRACT: Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).

SUBMITTER: Decreau RA

PROVIDER: S-EPMC2532528 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature

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Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry.

Decréau Richard A RA Collman James P JP Yang Ying Y Yan Yilong Y Devaraj Neal K NK

The Journal of organic chemistry 20070322 8

Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry). ...[more]

PMID: 17375955

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