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Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.


ABSTRACT: 5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators.

SUBMITTER: Schneider C 

PROVIDER: S-EPMC2532595 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.

Schneider Claus C   Boeglin William E WE   Yin Huiyong H   Stec Donald F DF   Voehler Markus M  

Journal of the American Chemical Society 20060101 3


5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound o  ...[more]

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