Unknown

Dataset Information

0

Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.


ABSTRACT: 5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators.

SUBMITTER: Schneider C 

PROVIDER: S-EPMC2532595 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.

Schneider Claus C   Boeglin William E WE   Yin Huiyong H   Stec Donald F DF   Voehler Markus M  

Journal of the American Chemical Society 20060101 3


5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound o  ...[more]

Similar Datasets

| S-EPMC3199522 | biostudies-literature
| S-EPMC6728142 | biostudies-literature
| S-EPMC4231669 | biostudies-literature
| S-EPMC5591212 | biostudies-literature
| S-EPMC2652760 | biostudies-literature
| S-EPMC7347166 | biostudies-literature
| S-EPMC2879920 | biostudies-literature
| S-EPMC2990155 | biostudies-literature
| S-EPMC10838593 | biostudies-literature
| S-EPMC4367288 | biostudies-literature