Ontology highlight
ABSTRACT:
SUBMITTER: Schneider C
PROVIDER: S-EPMC2532595 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Schneider Claus C Boeglin William E WE Yin Huiyong H Stec Donald F DF Voehler Markus M
Journal of the American Chemical Society 20060101 3
5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound o ...[more]