The triple helix: 50 years later, the outcome.
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ABSTRACT:
SUBMITTER: Duca M
PROVIDER: S-EPMC2532714 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
The triple helix: 50 years later, the outcome.
Duca Maria M Vekhoff Pierre P Oussedik Kahina K Halby Ludovic L Arimondo Paola B PB
Nucleic acids research 20080801 16
Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discover ...[more]
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