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N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis.

ABSTRACT: The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 directly and mediates wild-type p53-dependent transactivation. In addition, silencing of NDRG2 attenuates p53-mediated apoptosis, whereas overexpression of NDRG2 suppresses tumor cell growth, regardless of the presence or absence of p53. Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway.

SUBMITTER: Liu N

PROVIDER: S-EPMC2532733 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis.

Liu Na N Wang Lifeng L Li Xia X Yang Qi Q Liu Xinping X Zhang Jing J Zhang Jian J Wu Yousheng Y Ji Shaoping S Zhang Yingqi Y Yang Angang A Han Hua H Yao Libo L

Nucleic acids research 20080809 16

The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 dire ...[more]

PMID: 18689861

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A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy.

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N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.

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