Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.
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ABSTRACT:
SUBMITTER: Gravett MG
PROVIDER: S-EPMC2532920 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Publications
Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.
Gravett Michael G MG Thomas Archana A Schneider Kimberly A KA Reddy Ashok P AP Dasari Surendra S Jacob Thomas T Lu Xinfang X Rodland Matthew M Pereira Leonardo L Sadowsky Drew W DW Roberts Charles T CT Novy Miles J MJ Nagalla Srinivasa R SR
Journal of proteome research 20070101 1
Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunod ...[more]
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