Ontology highlight
ABSTRACT:
SUBMITTER: Parhi AK
PROVIDER: S-EPMC2532952 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Parhi Ajit K AK Wang Julie L JL Oya Shunichi S Choi Seok-Rye SR Kung Mei-Ping MP Kung Hank F HF
Journal of medicinal chemistry 20071204 26
A novel series of ligands with substitutions at the 5-position on phenyl ring A and at the 4'-position on phenyl ring B of 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine (4'-2-fluoroethoxy derivatives 28-31 and 4'-3-fluoropropoxy derivatives 40-42) were prepared and tested as serotonin transporter (SERT) imaging agents. The new ligands displayed high binding affinities to SERT (Ki ranging from 0.03 to 1.4 nM). The corresponding 18F labeled compounds, which can be prepared ...[more]