Ontology highlight
ABSTRACT:
SUBMITTER: Berman DE
PROVIDER: S-EPMC2532986 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Berman Diego E DE Dall'Armi Claudia C Voronov Sergey V SV McIntire Laura Beth J LB Zhang Hong H Moore Ann Z AZ Staniszewski Agniezka A Arancio Ottavio O Kim Tae-Wan TW Di Paolo Gilbert G
Nature neuroscience 20080406 5
Synaptic dysfunction caused by oligomeric assemblies of amyloid-beta peptide (Abeta) has been linked to cognitive deficits in Alzheimer's disease. Here we found that incubation of primary cortical neurons with oligomeric Abeta decreases the level of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), a phospholipid that regulates key aspects of neuronal function. The destabilizing effect of Abeta on PtdIns(4,5)P2 metabolism was Ca2+-dependent and was not observed in neurons that were derived ...[more]