Ontology highlight
ABSTRACT:
SUBMITTER: Kubota T
PROVIDER: S-EPMC2533075 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Kubota Toru T Matsuoka Mayumi M Chang Tsung-Hsien TH Tailor Prafullakumar P Sasaki Tsuguo T Tashiro Masato M Kato Atsushi A Ozato Keiko K
The Journal of biological chemistry 20080717 37
Viral infection activates Toll-like receptor and RIG-I (retinoic acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity. We show that upon vesicular stomatitis virus infection, IRF3 and IRF7 are modified not only by phosphorylation but by the small ubiquitin-related modifiers SUMO1, SUMO2, and SUMO3. SUMOylation of IRF3 and IRF7 was de ...[more]