Ontology highlight
ABSTRACT:
SUBMITTER: Bandyopadhyay S
PROVIDER: S-EPMC2533128 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Bandyopadhyay Subhajit S Zhou Wenjun W Breslow Ronald R
Organic letters 20070223 6
Isotactic polyethylenimines with (S)-benzyl side chains were synthesized from 4-(S)-4-benzyl-2-oxazolines. When alpha-keto acids were subjected to transamination in the presence of this polymer, and a pyridoxamine coenzyme modified with hydrophobic chains, enantioselectivity toward the natural isomer (l > d) was observed, followed by racemization of the amino acid products. However, the racemization did not occur when the coenzyme was covalently attached to the polymer. [reaction: see text] ...[more]